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FLASH GENE

Symbol

DYRK1B

contributors: mct/pg - updated : 01-10-2010

HGNC name	dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B
HGNC id	3092

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

EXPRESSION

Type	restricted

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Reproductive male system testis     predominantly Mus musculus

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Muscular striatum skeletal   highly Homo sapiens

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a bipartite nuclear localization signal (NLS)
	a putative leucine zipper motif and a conserved histidine repeat

HOMOLOGY

interspecies	homolog to Drosophila minibrain
	homolog to murine Dres27

Homologene

FAMILY	protein kinase superfamily
	Dyrk/Minibrain family of dual-specificity kinases
	CMGC Ser/Thr protein kinase family
	MNB/DYRK subfamily

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,nucleus

basic FUNCTION	serine/threonine and tyrosine kinase,involved in the regulation of nuclear functions
	multifunctional Ser/Thr kinase that plays a critical role in muscle differentiation by regulatory effects on motility, transcription, cell cycle progression, and cell survival
	acts as a survival factor in lung cancer cells
	putatively involved in cell growth and development
	effector molecule of activated RAS
	involved in linking mutant RAS to the inhibition of canonical HH signaling
	mediates cell cycle and survival via interacting with MAPK/ERK signals and simultaneous inhibition of both pathways
	mediates G0/G1 to S phase cell cycle progression and cell survival involving MAPK/ERK signaling in human cancer cells

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

CIRBP forms a complex together with DYRK1B and CCND1

INTERACTION

DNA

RNA

small molecule

protein	HNF1A (an HNF1alpha transcriptional activator in response to an MKK3-mediated stress signal, and the selective expression of DCOHM could restrict the DYRK1B response to carcinoma cells)
	DCOHM (DYRK1B binding protein)
	blocks quiescent cells from traversing G1 phase of the cell cycle by phosphorylating and destabilizing CCND1 and CCND3
	DYRK1A, DYRK1B, bind to the evolutionary conserved DCAF7 protein
	NKX3-1 and DYRK1B were shown to interact via the DYRK1B kinase domain
	critical positive regulator of HH/GLI signaling downstream of SMO

cell & other

REGULATION

activated by

MAP2K3

ASSOCIATED DISORDERS

corresponding disease(s)

AOMS3

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   in colon carcinoma tumoral     --over   in solid tumors and mediates cell survival in colon cancer, pancreatic ductal adenocarcinoma and rhabdomyosarcomas constitutional         -

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed cancer bone   promising target for molecular therapy in the treatment of osteosarcoma cancer lung   may be a novel therapeutic target in lung cancer cancer     may be a novel therapeutic target for human cancer

ANIMAL & CELL MODELS