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FLASH GENE
Symbol DYRK1B contributors: mct/pg - updated : 01-10-2010
HGNC name dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B
HGNC id 3092
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
11 - 2540 69.07 629 - 2002 11980910
11 - 2420 64.8 589 - 2002 11980910
12 - 2456 66.21 601 - 2002 11980910
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Reproductivemale systemtestis  predominantly Mus musculus
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumskeletal highly Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a bipartite nuclear localization signal (NLS)
  • a putative leucine zipper motif and a conserved histidine repeat
  • HOMOLOGY
    interspecies homolog to Drosophila minibrain
    homolog to murine Dres27
    Homologene
    FAMILY
  • protein kinase superfamily
  • Dyrk/Minibrain family of dual-specificity kinases
  • CMGC Ser/Thr protein kinase family
  • MNB/DYRK subfamily
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • serine/threonine and tyrosine kinase,involved in the regulation of nuclear functions
  • multifunctional Ser/Thr kinase that plays a critical role in muscle differentiation by regulatory effects on motility, transcription, cell cycle progression, and cell survival
  • acts as a survival factor in lung cancer cells
  • putatively involved in cell growth and development
  • effector molecule of activated RAS
  • involved in linking mutant RAS to the inhibition of canonical HH signaling
  • mediates cell cycle and survival via interacting with MAPK/ERK signals and simultaneous inhibition of both pathways
  • mediates G0/G1 to S phase cell cycle progression and cell survival involving MAPK/ERK signaling in human cancer cells
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • CIRBP forms a complex together with DYRK1B and CCND1
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • HNF1A (an HNF1alpha transcriptional activator in response to an MKK3-mediated stress signal, and the selective expression of DCOHM could restrict the DYRK1B response to carcinoma cells)
  • DCOHM (DYRK1B binding protein)
  • blocks quiescent cells from traversing G1 phase of the cell cycle by phosphorylating and destabilizing CCND1 and CCND3
  • DYRK1A, DYRK1B, bind to the evolutionary conserved DCAF7 protein
  • NKX3-1 and DYRK1B were shown to interact via the DYRK1B kinase domain
  • critical positive regulator of HH/GLI signaling downstream of SMO
  • cell & other
    REGULATION
    activated by MAP2K3
    ASSOCIATED DISORDERS
    corresponding disease(s) AOMS3
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in colon carcinoma
    tumoral     --over  
    in solid tumors and mediates cell survival in colon cancer, pancreatic ductal adenocarcinoma and rhabdomyosarcomas
    constitutional        
    -
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerbone 
    promising target for molecular therapy in the treatment of osteosarcoma
    cancerlung 
    may be a novel therapeutic target in lung cancer
    cancer  
    may be a novel therapeutic target for human cancer
    ANIMAL & CELL MODELS