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FLASH GENE
Symbol AGXT contributors: mct - updated : 01-09-2009
HGNC name alanine-glyoxylate aminotransferase
HGNC id 341
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • C-terminal tripeptide (KKL) are unlike those of any other type 1 peroxisomal targeting sequence (PTS1)
    • mono polymer homomer , dimer
    HOMOLOGY
    interspecies homolog to murine Agset
    homolog to C.elegans t14d7.1
    Homologene
    FAMILY
  • class V of pyridoxal-phosphate-dependent aminotransferases family
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,peroxisome
    text mitochondrial matrix in some ph1 patients
    basic FUNCTION
  • involved in glyoxylate detoxification
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS excretion
    text glyoxylate detoxication
    PATHWAY
    metabolism other
    signaling
    glyoxylate cycle pyruvate metabolism
    a component
    INTERACTION
    DNA
    RNA
    small molecule cofactor,
  • pyridoxal phosphate
    • protein
  • interacts with PEX5
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) PHXL1
    related resource MITOP database
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS