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FLASH GENE
Symbol AGXT contributors: mct - updated : 01-09-2009
HGNC name alanine-glyoxylate aminotransferase
HGNC id 341
EXPRESSION
Type restricted
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveliver    
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • C-terminal tripeptide (KKL) are unlike those of any other type 1 peroxisomal targeting sequence (PTS1)
    • mono polymer homomer , dimer
    HOMOLOGY
    interspecies homolog to murine Agset
    homolog to C.elegans t14d7.1
    Homologene
    FAMILY
  • class V of pyridoxal-phosphate-dependent aminotransferases family
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,peroxisome
    text mitochondrial matrix in some ph1 patients
    basic FUNCTION
  • involved in glyoxylate detoxification
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS excretion
    text glyoxylate detoxication
    PATHWAY
    metabolism other
    signaling
    glyoxylate cycle pyruvate metabolism
    a component
    INTERACTION
    DNA
    RNA
    small molecule cofactor,
  • pyridoxal phosphate
    • protein
  • interacts with PEX5
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) PHXL1
    related resource MITOP database
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS