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FLASH GENE

Symbol

AGXT

contributors: mct - updated : 01-09-2009

HGNC name	alanine-glyoxylate aminotransferase
HGNC id	341

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	10.37 kb     11 Exon(s)    1 Copie(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

confirmed

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_000030 11 - 1611 NP_000021 - 392 - 2009 19479957

EXPRESSION

Type	restricted

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive liver

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

C-terminal tripeptide (KKL) are unlike those of any other type 1 peroxisomal targeting sequence (PTS1)

mono polymer

homomer , dimer

HOMOLOGY

interspecies	homolog to murine Agset
	homolog to C.elegans t14d7.1

Homologene

FAMILY

class V of pyridoxal-phosphate-dependent aminotransferases family

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,peroxisome
text	mitochondrial matrix in some ph1 patients

basic FUNCTION

involved in glyoxylate detoxification

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

excretion

text	glyoxylate detoxication

PATHWAY

metabolism

other

signaling

glyoxylate cycle pyruvate metabolism

a component

INTERACTION

DNA

RNA

small molecule	cofactor,
	pyridoxal phosphate

protein

interacts with PEX5

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

PHXL1

related resource

MITOP database

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS