| basic FUNCTION
| SNF2-related helicase, functioning as a coactivator of steroid receptor-mediated transcription through synergistic interactions with CARM1 and NCOA2 |
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functioning as a glucocorticoid receptor coactivator |
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ATPase chromatin-remodeling machine, implicated in the transcriptional coactivation of cyclic AMP- and steroid-dependent promoters |
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SRCAP complex catalyzes ATP-dependent exchange of histone H2A/H2B dimers containing the histone variant H2A.Z into nucleosomes  |
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having a coactivator function that may depend on its ability to promote incorporation of H2AFZ into chromatin |
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could catalyze deposition of H2AFZ into nucleosomes |
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recruited to promoters and is critical for the deposition of H2AFZ |
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ATPase that is the core subunit of a large multiprotein complex and was shown to incorporate the histone variant H2A.Z into nucleosomes |
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serves as a coactivator for several nuclear receptors including the androgen receptor (AR) |
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activates hormone-dependent transcription of the androgen responsive, prostate specific antigen (PSA)-Luciferase reporter gene in human prostate cells |
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plays a role in prostate cancer cell proliferation |
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SNF2-related chromatin-remodeling factor that serves as a coactivator for CREB-binding protein (CREBBP) |
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undergoes a large conformational change upon nucleosome binding |
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SRCAP chromatin remodeling complex is a novel regulator of DNA damage responses that orchestrates proper signaling and repair of DSBs in the context of chromatin |
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important physiological functions of the SRCAP complex in regulating mitochondrial maturation and promoting oxidative metabolism during heart development |
