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FLASH GENE
Symbol SRCAP contributors: mct/pgu - updated : 23-06-2021
HGNC name Snf2-related CREBBP activator protein
HGNC id 16974
Corresponding disease
DHBPA developmental delay, hypotonia, behavioral and psychiatric anomalies
FLHS Floating-Harbor syndrome
Location 16p11.2      Physical location : 30.710.461 - 30.751.449
Genatlas name Snf2-related CBP activator protein
Synonym name
  • cDNA sequence, expressed in brain, >100kDa, related to 218kDa MI2
  • Snf2-related CBP activator protein
  • Swi2/Snf2-related ATPase homolog, domino homolog 1
  • domino homolog 2
    • Synonym symbol(s) KIAA0309, DOMO1, EAF1, FLJ44499, SWR1
    DNA
    TYPE functioning gene
    STRUCTURE 40.98 kb     34 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    34 - 10491 - 3230 - 2007 17617668
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinelarge intestinecolon highly
     salivary gland   highly
    Nervousbrain    
    Reproductivemale systemprostate  highly Homo sapiens
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialbarrier lininguroepithelium   Homo sapiens
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Reproductiveepithelial cell Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • N-terminal region binding to H2AFZ and containing the helicase-SANT-associated (HSA) domain, critical for protein association, including association of actin and actin-related proteins (Wu 2009)
    • mono polymer heptamer
    HOMOLOGY
    interspecies homolog to drosophila Dom
    intraspecies homolog to 218kDa MI2
    Homologene
    FAMILY SNF2 ATPase family
    CATEGORY enzyme , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,Golgi
    intracellular,nucleus,nucleoplasm,nuclear bodies
    intracellular,nucleus,chromatin/chromosome,nucleosome
    intracellular,nuclear envelope
    basic FUNCTION
  • SNF2-related helicase, functioning as a coactivator of steroid receptor-mediated transcription through synergistic interactions with CARM1 and NCOA2
  • functioning as a glucocorticoid receptor coactivator
  • ATPase chromatin-remodeling machine, implicated in the transcriptional coactivation of cyclic AMP- and steroid-dependent promoters
  • SRCAP complex catalyzes ATP-dependent exchange of histone H2A/H2B dimers containing the histone variant H2A.Z into nucleosomes
  • having a coactivator function that may depend on its ability to promote incorporation of H2AFZ into chromatin
  • could catalyze deposition of H2AFZ into nucleosomes
  • recruited to promoters and is critical for the deposition of H2AFZ
  • ATPase that is the core subunit of a large multiprotein complex and was shown to incorporate the histone variant H2A.Z into nucleosomes
  • serves as a coactivator for several nuclear receptors including the androgen receptor (AR)
  • activates hormone-dependent transcription of the androgen responsive, prostate specific antigen (PSA)-Luciferase reporter gene in human prostate cells
  • plays a role in prostate cancer cell proliferation
  • SNF2-related chromatin-remodeling factor that serves as a coactivator for CREB-binding protein (CREBBP)
  • undergoes a large conformational change upon nucleosome binding
  • SRCAP chromatin remodeling complex is a novel regulator of DNA damage responses that orchestrates proper signaling and repair of DSBs in the context of chromatin
  • important physiological functions of the SRCAP complex in regulating mitochondrial maturation and promoting oxidative metabolism during heart development
    • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    function in the notch signaling pathway
    a component
  • part of a multiprotein complex, SRCAP-containing complex supporting ATP-dependent exchange of histone dimers containing H2B and H2AFZ into mononucleosomes reconstituted with recombinant H2A, H2B, H3, and H4
  • a single heterohexameric RVB1/RVB2 ring that, together with the catalytic subunit SWR1, brackets two independently assembled multisubunit modules
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • with CBP (cAMP response element binding protein), functioning as a coactivator to regulate transcription initiated by several signaling pathways
  • functionally interacts with NCOA2 and CARM1
  • potent coactivator for CREB and CBP-mediated transcription
  • interacting with Hepatitis C virus NS3 protein (can activate the Notch-signaling pathway through binding to SRCAP)
  • PCID2 controls lymphoid lineage commitment through the regulation of SRCAP remodelling activity
  • mechanistically, SRCAP recruits the transcriptional regulator REST to the PRDM16 promoter and induces expression of this transcription factor
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) FLHS , DHBPA
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS