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FLASH GENE
Symbol SRCAP contributors: mct/pgu - updated : 23-06-2021
HGNC name Snf2-related CREBBP activator protein
HGNC id 16974
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinelarge intestinecolon highly
 salivary gland   highly
Nervousbrain    
Reproductivemale systemprostate  highly Homo sapiens
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialbarrier lininguroepithelium   Homo sapiens
cells
SystemCellPubmedSpeciesStageRna symbol
Reproductiveepithelial cell Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N-terminal region binding to H2AFZ and containing the helicase-SANT-associated (HSA) domain, critical for protein association, including association of actin and actin-related proteins (Wu 2009)
  • mono polymer heptamer
    HOMOLOGY
    interspecies homolog to drosophila Dom
    intraspecies homolog to 218kDa MI2
    Homologene
    FAMILY SNF2 ATPase family
    CATEGORY enzyme , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,Golgi
    intracellular,nucleus,nucleoplasm,nuclear bodies
    intracellular,nucleus,chromatin/chromosome,nucleosome
    intracellular,nuclear envelope
    basic FUNCTION
  • SNF2-related helicase, functioning as a coactivator of steroid receptor-mediated transcription through synergistic interactions with CARM1 and NCOA2
  • functioning as a glucocorticoid receptor coactivator
  • ATPase chromatin-remodeling machine, implicated in the transcriptional coactivation of cyclic AMP- and steroid-dependent promoters
  • SRCAP complex catalyzes ATP-dependent exchange of histone H2A/H2B dimers containing the histone variant H2A.Z into nucleosomes
  • having a coactivator function that may depend on its ability to promote incorporation of H2AFZ into chromatin
  • could catalyze deposition of H2AFZ into nucleosomes
  • recruited to promoters and is critical for the deposition of H2AFZ
  • ATPase that is the core subunit of a large multiprotein complex and was shown to incorporate the histone variant H2A.Z into nucleosomes
  • serves as a coactivator for several nuclear receptors including the androgen receptor (AR)
  • activates hormone-dependent transcription of the androgen responsive, prostate specific antigen (PSA)-Luciferase reporter gene in human prostate cells
  • plays a role in prostate cancer cell proliferation
  • SNF2-related chromatin-remodeling factor that serves as a coactivator for CREB-binding protein (CREBBP)
  • undergoes a large conformational change upon nucleosome binding
  • SRCAP chromatin remodeling complex is a novel regulator of DNA damage responses that orchestrates proper signaling and repair of DSBs in the context of chromatin
  • important physiological functions of the SRCAP complex in regulating mitochondrial maturation and promoting oxidative metabolism during heart development
  • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    function in the notch signaling pathway
    a component
  • part of a multiprotein complex, SRCAP-containing complex supporting ATP-dependent exchange of histone dimers containing H2B and H2AFZ into mononucleosomes reconstituted with recombinant H2A, H2B, H3, and H4
  • a single heterohexameric RVB1/RVB2 ring that, together with the catalytic subunit SWR1, brackets two independently assembled multisubunit modules
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • with CBP (cAMP response element binding protein), functioning as a coactivator to regulate transcription initiated by several signaling pathways
  • functionally interacts with NCOA2 and CARM1
  • potent coactivator for CREB and CBP-mediated transcription
  • interacting with Hepatitis C virus NS3 protein (can activate the Notch-signaling pathway through binding to SRCAP)
  • PCID2 controls lymphoid lineage commitment through the regulation of SRCAP remodelling activity
  • mechanistically, SRCAP recruits the transcriptional regulator REST to the PRDM16 promoter and induces expression of this transcription factor
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) FLHS , DHBPA
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS