Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol CALU contributors: mct - updated : 04-03-2019
HGNC name calumenin
HGNC id 1458
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • six EF-hand domains
  • potential N-glycosylation site
  • at the C terminus a HDEF sequence, retrieval signal and an ER retention signal
  • HOMOLOGY
    interspecies homolog to murine Calu
    Homologene
    FAMILY CREC family of Ca2+-binding proteins having multiple EF-hands
    CATEGORY chaperone/stress , transport
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,organelle,Golgi
    text demonstrated in the ER as well as in the Golgi complex
    basic FUNCTION
  • calumenin CA++ binding proteins in the ER and Golgi apparatus
  • involved in such ER functions as protein folding and sorting
  • may participate in the immunological defense system and could be involved in the pathological process of amyloidosis that leads to formation of amyloid deposits seen in different types of tissues
  • may have an autocrine or a paracrine effect on the cells in its vicinity, and, therefore, may be involved in the pathophysiology of thrombosis or in wound healing (
  • influence the synthesis of certain coagulation factors
  • may be broadly involved in haemostasis and in the pathophysiology of thrombosis
  • potential novel regulator of ATP2A2, and its expressional changes are tightly coupled with Ca(2+)-cycling of cardiomyocytes
  • possible important role of CALU in migration and differentiation of neurons, and/or in Ca(2+) signaling between glial cells and neuron
  • extracellular calumenin as a suppressor of cell migration and tumor metastasis
  • calumenin regulates FBLN1 to have crucial roles in ERK1/2 signaling and cell migration
  • is a Ca2+ sensor, which folds into a compact structure, capable of interacting with its molecular partners, when Ca2+ concentration within the ER reaches the millimolar range
  • multi-EF-hand-containing Ca2+-binding protein
  • is intrinsically unstructured in the Ca2+ free form and responds to Ca2+ with a dramatic gain in structure
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with TSP1 (in the presence of Ca(2+) binds to TSP1)
  • interacts with RYR2 and ATP2A2, and therefore changes in the expression of calumenin could potentially alter Ca2+ cycling in heart
  • CALU binds to and stabilizes FBLN1, leading to inactivation of extracellular signal-regulated kinases 1 and 2 (ERK1/2) signaling
  • MMP13 proteolyzes FBLN1 and CALU protects FBLN1 from cleavage by MMP13
  • CALU inhibits gamma-carboxylation of MGP preventing BMP2-dependent calcification
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    respiratoryCF (mucoviscidosis) 
    modulation of CALU expression or activity may be used as a potential therapeutic tool to correct defects in F508del-CFTR
    ANIMAL & CELL MODELS