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FLASH GENE
Symbol CALU contributors: mct - updated : 04-03-2019
HGNC name calumenin
HGNC id 1458
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
8 - 6181 - 323 - 1999 10222138
8 - 6181 - 323 - 1999 10222138
7 - 5366 - 315 - 1999 10222138
6 - 5166 - 224 - 1999 10222138
7 - 5366 - 315 - 1999 10222138
5 - 4940 - 164 - 1999 10222138
- - - - - shuttles between the nucleus and cytoplasm through interacting with importin alpha, Ran GTPase, and CRM1 2013 24136234
  • promotes filopodia formation and cell migration
  • in the nucleus, CALU-15 increases the transcription of growth differentiation factor-15 (GDF15) (PMID: 24136234)
  • EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   highly Homo sapiensFetal
    Nervousbrainlimbic systemhippocampusdentate gyrus  Homo sapiensFetal
    Skin/Tegumentskin   highly
    Urinarykidney   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow  highly
    Connectivebone  highly
    Muscularstriatumskeletal  
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticplatelet Homo sapiens
    Nervousglia Homo sapiensFetal
    Nervousneuron Homo sapiensFetal
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • six EF-hand domains
  • potential N-glycosylation site
  • at the C terminus a HDEF sequence, retrieval signal and an ER retention signal
  • HOMOLOGY
    interspecies homolog to murine Calu
    Homologene
    FAMILY CREC family of Ca2+-binding proteins having multiple EF-hands
    CATEGORY chaperone/stress , transport
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,organelle,Golgi
    text demonstrated in the ER as well as in the Golgi complex
    basic FUNCTION
  • calumenin CA++ binding proteins in the ER and Golgi apparatus
  • involved in such ER functions as protein folding and sorting
  • may participate in the immunological defense system and could be involved in the pathological process of amyloidosis that leads to formation of amyloid deposits seen in different types of tissues
  • may have an autocrine or a paracrine effect on the cells in its vicinity, and, therefore, may be involved in the pathophysiology of thrombosis or in wound healing (
  • influence the synthesis of certain coagulation factors
  • may be broadly involved in haemostasis and in the pathophysiology of thrombosis
  • potential novel regulator of ATP2A2, and its expressional changes are tightly coupled with Ca(2+)-cycling of cardiomyocytes
  • possible important role of CALU in migration and differentiation of neurons, and/or in Ca(2+) signaling between glial cells and neuron
  • extracellular calumenin as a suppressor of cell migration and tumor metastasis
  • calumenin regulates FBLN1 to have crucial roles in ERK1/2 signaling and cell migration
  • is a Ca2+ sensor, which folds into a compact structure, capable of interacting with its molecular partners, when Ca2+ concentration within the ER reaches the millimolar range
  • multi-EF-hand-containing Ca2+-binding protein
  • is intrinsically unstructured in the Ca2+ free form and responds to Ca2+ with a dramatic gain in structure
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with TSP1 (in the presence of Ca(2+) binds to TSP1)
  • interacts with RYR2 and ATP2A2, and therefore changes in the expression of calumenin could potentially alter Ca2+ cycling in heart
  • CALU binds to and stabilizes FBLN1, leading to inactivation of extracellular signal-regulated kinases 1 and 2 (ERK1/2) signaling
  • MMP13 proteolyzes FBLN1 and CALU protects FBLN1 from cleavage by MMP13
  • CALU inhibits gamma-carboxylation of MGP preventing BMP2-dependent calcification
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    respiratoryCF (mucoviscidosis) 
    modulation of CALU expression or activity may be used as a potential therapeutic tool to correct defects in F508del-CFTR
    ANIMAL & CELL MODELS