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FLASH GENE
Symbol CALU contributors: mct - updated : 04-03-2019
HGNC name calumenin
HGNC id 1458
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   highly Homo sapiensFetal
Nervousbrainlimbic systemhippocampusdentate gyrus  Homo sapiensFetal
Skin/Tegumentskin   highly
Urinarykidney   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / hematopoieticbone marrow  highly
Connectivebone  highly
Muscularstriatumskeletal  
cells
SystemCellPubmedSpeciesStageRna symbol
Blood/Hematopoieticplatelet Homo sapiens
Nervousglia Homo sapiensFetal
Nervousneuron Homo sapiensFetal
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period pregnancy
Text placenta
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • six EF-hand domains
  • potential N-glycosylation site
  • at the C terminus a HDEF sequence, retrieval signal and an ER retention signal
  • HOMOLOGY
    interspecies homolog to murine Calu
    Homologene
    FAMILY CREC family of Ca2+-binding proteins having multiple EF-hands
    CATEGORY chaperone/stress , transport
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,organelle,Golgi
    text demonstrated in the ER as well as in the Golgi complex
    basic FUNCTION
  • calumenin CA++ binding proteins in the ER and Golgi apparatus
  • involved in such ER functions as protein folding and sorting
  • may participate in the immunological defense system and could be involved in the pathological process of amyloidosis that leads to formation of amyloid deposits seen in different types of tissues
  • may have an autocrine or a paracrine effect on the cells in its vicinity, and, therefore, may be involved in the pathophysiology of thrombosis or in wound healing (
  • influence the synthesis of certain coagulation factors
  • may be broadly involved in haemostasis and in the pathophysiology of thrombosis
  • potential novel regulator of ATP2A2, and its expressional changes are tightly coupled with Ca(2+)-cycling of cardiomyocytes
  • possible important role of CALU in migration and differentiation of neurons, and/or in Ca(2+) signaling between glial cells and neuron
  • extracellular calumenin as a suppressor of cell migration and tumor metastasis
  • calumenin regulates FBLN1 to have crucial roles in ERK1/2 signaling and cell migration
  • is a Ca2+ sensor, which folds into a compact structure, capable of interacting with its molecular partners, when Ca2+ concentration within the ER reaches the millimolar range
  • multi-EF-hand-containing Ca2+-binding protein
  • is intrinsically unstructured in the Ca2+ free form and responds to Ca2+ with a dramatic gain in structure
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with TSP1 (in the presence of Ca(2+) binds to TSP1)
  • interacts with RYR2 and ATP2A2, and therefore changes in the expression of calumenin could potentially alter Ca2+ cycling in heart
  • CALU binds to and stabilizes FBLN1, leading to inactivation of extracellular signal-regulated kinases 1 and 2 (ERK1/2) signaling
  • MMP13 proteolyzes FBLN1 and CALU protects FBLN1 from cleavage by MMP13
  • CALU inhibits gamma-carboxylation of MGP preventing BMP2-dependent calcification
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    respiratoryCF (mucoviscidosis) 
    modulation of CALU expression or activity may be used as a potential therapeutic tool to correct defects in F508del-CFTR
    ANIMAL & CELL MODELS