Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol GSTA1 contributors: mct/npt - updated : 15/102008
HGNC name glutathione S-transferase A1
HGNC id 4626
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
mono polymer homomer , heteromer , dimer
HOMOLOGY
Homologene
FAMILY
  • GST superfamily
  • MU family
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • conjugating reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles
  • suppresses activation of JNK signalling by a pro-inflammatory cytokine and oxidative stress and have likely a protective role in JNK-associated apoptosis
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • dimer of A1 and A2
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in high-grade prostatic intraepithelial neoplasia
    constitutional     --over  
    overexpressed in proliferative inflammatory atrophy
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS