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FLASH GENE
Symbol GSTA1 contributors: mct/npt - updated : 15/102008
HGNC name glutathione S-transferase A1
HGNC id 4626
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveliver   highly
 pharynx   highly
Endocrineadrenal gland   highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
mono polymer homomer , heteromer , dimer
HOMOLOGY
Homologene
FAMILY
  • GST superfamily
  • MU family
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • conjugating reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles
  • suppresses activation of JNK signalling by a pro-inflammatory cytokine and oxidative stress and have likely a protective role in JNK-associated apoptosis
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • dimer of A1 and A2
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in high-grade prostatic intraepithelial neoplasia
    constitutional     --over  
    overexpressed in proliferative inflammatory atrophy
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS