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FLASH GENE

Symbol

GSTA1

contributors: mct/npt - updated : 15/102008

HGNC name	glutathione S-transferase A1
HGNC id	4626

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
SPECIAL FEATURE	component of a cluster, head to head
text	closely flanked by other alpha class gene sequences
STRUCTURE	12.27 kb     7 Exon(s)

10 Kb 5' upstream gene genomic sequence study

text structure

a proximal promoter essential for the binding of activating transcription factor complexes

MAPPING

cloned

Y

linked

N

status

provisional

Map	cen - ICK - GSTA@ - qter
Authors	Morel (02)

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed variant 1 7 - 1046 - 222 - Johnson (2008)

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive liver       highly   pharynx       highly Endocrine adrenal gland       highly

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

mono polymer

homomer , heteromer , dimer

HOMOLOGY

Homologene

FAMILY	GST superfamily
	MU family

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm

basic FUNCTION	conjugating reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles
	suppresses activation of JNK signalling by a pro-inflammatory cytokine and oxidative stress and have likely a protective role in JNK-associated apoptosis

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

dimer of A1 and A2

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --low   in high-grade prostatic intraepithelial neoplasia constitutional     --over   overexpressed in proliferative inflammatory atrophy

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS