Selected-GenAtlas references	SOURCE	GeneCards	NCBI Gene	Swiss-Prot	Ensembl
	HGNC	UniGene	Nucleotide	OMIM	UCSC

Home Page

FLASH GENE

Symbol

RAD54L

contributors: mct/npt - updated : 08-07-2008

HGNC name	RAD54-like (S. cerevisiae)
HGNC id	9826

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

helicase conserved C terminal domain

HOMOLOGY

interspecies

homolog to yeast S.cerevisiae RAD54

Homologene

FAMILY	SNF2/RAD54 helicase family
	RAD52 epistasis group

CATEGORY

enzyme , DNA associated , tumor suppressor

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,nucleus

basic FUNCTION

recombinational protein associated with RAD51, involved in nucleotide excision repair of double-strand break and in meiotic recombination

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral   LOH     in breast cancer

Susceptibility

to pancreatic cancer to meningiomas

Variant & Polymorphism other	variants affect clinical prognosis of patients with pancreatic cancer
	association between the rare T allele and the development of meningeal tumours

Candidate gene	potential tumor suppressor in parathyroid adenoma (see TSG1J), breast cancer with poor prognosis and oligodendroglioma (see TSG1A)
Marker
Therapy target

ANIMAL & CELL MODELS