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FLASH GENE
Symbol RAD54L contributors: mct/npt - updated : 08-07-2008
HGNC name RAD54-like (S. cerevisiae)
HGNC id 9826
Location 1p32      Physical location : 46.713.366 - 46.744.145
Synonym name
  • RAD54 homolog
  • DNA repair and recombination protein RAD54-like
    • Synonym symbol(s) HR54, HRAD54, HHR54, RAD54A
    EC.number 3.6.1.-
    DNA
    TYPE functioning gene
    STRUCTURE 30.00 kb     18 Exon(s)
    Genomic sequence alignment details
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    regionally located localized in a region of high loss of heterozygosity in breast cancer
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    18 - 3107 84 747 - Sellick (2008)
    EXPRESSION
    Type widely
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivestomach   highly
    Lymphoid/Immunethymus   highly
    Reproductivefemale systemovary  highly
     male systemtestis  highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Lymphoid    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal, pregnancy
    cell cycle     cell cycle, checkpoint, G1S
    Text lymphoid development
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • helicase conserved C terminal domain
    • HOMOLOGY
    interspecies homolog to yeast S.cerevisiae RAD54
    Homologene
    FAMILY
  • SNF2/RAD54 helicase family
  • RAD52 epistasis group
    • CATEGORY enzyme , DNA associated , tumor suppressor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • recombinational protein associated with RAD51, involved in nucleotide excision repair of double-strand break and in meiotic recombination
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral   LOH    
    in breast cancer
    Susceptibility
  • to pancreatic cancer
  • to meningiomas
    • Variant & Polymorphism other
  • variants affect clinical prognosis of patients with pancreatic cancer
  • association between the rare T allele and the development of meningeal tumours
    • Candidate gene potential tumor suppressor in parathyroid adenoma (see TSG1J), breast cancer with poor prognosis and oligodendroglioma (see TSG1A)
    Marker
    Therapy target
    ANIMAL & CELL MODELS