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FLASH GENE

Symbol

RAD54L

contributors: mct/npt - updated : 08-07-2008

HGNC name	RAD54-like (S. cerevisiae)
HGNC id	9826

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	30.00 kb     18 Exon(s)

Genomic sequence alignment details
10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

confirmed

regionally located

localized in a region of high loss of heterozygosity in breast cancer

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed RAD54L 18 - 3107 84 747 - Sellick (2008)

EXPRESSION

Type

widely

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive stomach       highly Lymphoid/Immune thymus       highly Reproductive female system ovary     highly   male system testis     highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Lymphoid

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

fetal, pregnancy

cell cycle

cell cycle, checkpoint, G1S

Text	lymphoid development

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

helicase conserved C terminal domain

HOMOLOGY

interspecies

homolog to yeast S.cerevisiae RAD54

Homologene

FAMILY	SNF2/RAD54 helicase family
	RAD52 epistasis group

CATEGORY

enzyme , DNA associated , tumor suppressor

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,nucleus

basic FUNCTION

recombinational protein associated with RAD51, involved in nucleotide excision repair of double-strand break and in meiotic recombination

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral   LOH     in breast cancer

Susceptibility

to pancreatic cancer to meningiomas

Variant & Polymorphism other	variants affect clinical prognosis of patients with pancreatic cancer
	association between the rare T allele and the development of meningeal tumours

Candidate gene	potential tumor suppressor in parathyroid adenoma (see TSG1J), breast cancer with poor prognosis and oligodendroglioma (see TSG1A)
Marker
Therapy target

ANIMAL & CELL MODELS