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FLASH GENE
Symbol GPR21 contributors: mct - updated : 23-09-2013
HGNC name G protein-coupled receptor 21
HGNC id 4476
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
seven transmembrane segments (7TM) receptor
HOMOLOGY
Homologene
FAMILY G protein coupled receptor family
CATEGORY receptor
SUBCELLULAR LOCALIZATION     plasma membrane
basic FUNCTION
  • may play an important role in regulating body weight and glucose metabolism
  • has potentially a critical function in coordinating macrophage proinflammatory activity in the context of obesity-induced insulin resistance
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    diabetetype 2 
    may be a new therapeutic target in the treatment of obesity and diabetes
    ANIMAL & CELL MODELS
  • mice deficient for the Gpr21 gene were resistant to diet-induced obesity, and knockout mice were leaner than their wildtype counterpart, despite that no difference was observed in food intake