Selected-GenAtlas references	SOURCE	GeneCards	NCBI Gene	Swiss-Prot	Ensembl
	HGNC	UniGene	Nucleotide	OMIM	UCSC

Home Page

FLASH GENE

Symbol

GPR21

contributors: mct - updated : 23-09-2013

HGNC name	G protein-coupled receptor 21
HGNC id	4476

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive salivary gland       highly Mus musculus Lymphoid/Immune lymph node       highly Mus musculus   spleen       predominantly Mus musculus Nervous brain diencephalon hypothalamus   predominantly Mus musculus

cells

System Cell Pubmed Species Stage Rna symbol Lymphoid/Immune macrophage Mus musculus

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

seven transmembrane segments (7TM) receptor

HOMOLOGY

Homologene

FAMILY

G protein coupled receptor family

CATEGORY

receptor

SUBCELLULAR LOCALIZATION

plasma membrane

basic FUNCTION	may play an important role in regulating body weight and glucose metabolism
	has potentially a critical function in coordinating macrophage proinflammatory activity in the context of obesity-induced insulin resistance

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed diabete type 2   may be a new therapeutic target in the treatment of obesity and diabetes

ANIMAL & CELL MODELS

mice deficient for the Gpr21 gene were resistant to diet-induced obesity, and knockout mice were leaner than their wildtype counterpart, despite that no difference was observed in food intake