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FLASH GENE
Symbol GPR21 contributors: mct - updated : 23-09-2013
HGNC name G protein-coupled receptor 21
HGNC id 4476
Location 9q33.3      Physical location : 125.796.845 - 125.797.894
DNA
TYPE functioning gene
STRUCTURE 5.46 kb     2 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked   status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
2 - 1595 - 349 - 1997 9073069
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivesalivary gland   highly Mus musculus
Lymphoid/Immunelymph node   highly Mus musculus
 spleen   predominantly Mus musculus
Nervousbraindiencephalonhypothalamus predominantly Mus musculus
cells
SystemCellPubmedSpeciesStageRna symbol
Lymphoid/Immunemacrophage Mus musculus
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
seven transmembrane segments (7TM) receptor
HOMOLOGY
Homologene
FAMILY G protein coupled receptor family
CATEGORY receptor
SUBCELLULAR LOCALIZATION     plasma membrane
basic FUNCTION
  • may play an important role in regulating body weight and glucose metabolism
  • has potentially a critical function in coordinating macrophage proinflammatory activity in the context of obesity-induced insulin resistance
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    diabetetype 2 
    may be a new therapeutic target in the treatment of obesity and diabetes
    ANIMAL & CELL MODELS
  • mice deficient for the Gpr21 gene were resistant to diet-induced obesity, and knockout mice were leaner than their wildtype counterpart, despite that no difference was observed in food intake