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FLASH GENE
Symbol SSX2 contributors: mct/npt - updated : 04-10-2021
HGNC name synovial sarcoma, X breakpoint 2
HGNC id 11336
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a domain related to the KRAB domain of zinc finger proteins, at the N terminus
  • a highly acidic C terminus
    • HOMOLOGY
    interspecies homolog to C.elegans K02F6.6
    intraspecies homolog to Krüppel associated box,KRAB
    Homologene
    FAMILY
  • cancer/testis antigens family
  • SSX family
    • CATEGORY transcription factor , antigen , protooncogene
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleoplasm,nuclear bodies,nuclear speckles
    intracellular,nucleus,nucleolus
    basic FUNCTION
  • acting as a modulator of transcription
  • SSX2 is implicated in regulation of chromatin structure and function
  • SSX2-mediated replication stress translates likely into mitotic defects and genomic instability
  • regulates focal adhesion but does not drive the epithelial to mesenchymal transition in prostate cancer
  • Mediator complex is essential for SSX2-induced senescence, suggesting that changes in Mediator activity could be instrumental for tumorigenesis
    • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS immunity/defense
    text human tumor antigen MOM-MEL-40
    PATHWAY
    metabolism
    signaling
    a component
  • complexing with polycomb group (PcG) proteins RING1 or BMI1
    • INTERACTION
    DNA binding to chromatin
    RNA
    small molecule metal binding,
  • Zn2+
    • protein
  • SSX2 binds double-stranded DNA in a sequence non-specific manner in agreement with the observed widespread association with chromatin
  • reduced levels of MED1, MED4, and MED14 perturbed the development of senescence in SSX2-expressing cells
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) BSSX
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in hepatocellular carcinoma (Wu 2006)
    tumoral fusion      
  • fused with SYT (SSXT) in synovial sarcoma with translocation t(X;18)(p11.2;q11.2) (see BSSX)
    • tumoral fusion      
    SS18-SSX2 fusion oncogene expression characterizes human synovial sarcoma
    Susceptibility
    Variant & Polymorphism
    Candidate gene mRNA detect circulating HCC cells as adjuvant diagnostic tool and as indicators of recurrence and prognosis (Wu 2006)
    Marker
    Therapy target
    ANIMAL & CELL MODELS