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FLASH GENE
Symbol SSX2 contributors: mct/npt - updated : 04-10-2021
HGNC name synovial sarcoma, X breakpoint 2
HGNC id 11336
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Endocrinethyroid   lowly
Reproductivemale systemtestis  highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialsecretoryglandularendocrine 
cell lineage
cell lines several types of cancers, i.e. melanoma, rhabdomyosarcoma and fibrosarcoma
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a domain related to the KRAB domain of zinc finger proteins, at the N terminus
  • a highly acidic C terminus
  • HOMOLOGY
    interspecies homolog to C.elegans K02F6.6
    intraspecies homolog to Krüppel associated box,KRAB
    Homologene
    FAMILY
  • cancer/testis antigens family
  • SSX family
  • CATEGORY transcription factor , antigen , protooncogene
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleoplasm,nuclear bodies,nuclear speckles
    intracellular,nucleus,nucleolus
    basic FUNCTION
  • acting as a modulator of transcription
  • SSX2 is implicated in regulation of chromatin structure and function
  • SSX2-mediated replication stress translates likely into mitotic defects and genomic instability
  • regulates focal adhesion but does not drive the epithelial to mesenchymal transition in prostate cancer
  • Mediator complex is essential for SSX2-induced senescence, suggesting that changes in Mediator activity could be instrumental for tumorigenesis
  • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS immunity/defense
    text human tumor antigen MOM-MEL-40
    PATHWAY
    metabolism
    signaling
    a component
  • complexing with polycomb group (PcG) proteins RING1 or BMI1
  • INTERACTION
    DNA binding to chromatin
    RNA
    small molecule metal binding,
  • Zn2+
  • protein
  • SSX2 binds double-stranded DNA in a sequence non-specific manner in agreement with the observed widespread association with chromatin
  • reduced levels of MED1, MED4, and MED14 perturbed the development of senescence in SSX2-expressing cells
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) BSSX
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in hepatocellular carcinoma (Wu 2006)
    tumoral fusion      
  • fused with SYT (SSXT) in synovial sarcoma with translocation t(X;18)(p11.2;q11.2) (see BSSX)
  • tumoral fusion      
    SS18-SSX2 fusion oncogene expression characterizes human synovial sarcoma
    Susceptibility
    Variant & Polymorphism
    Candidate gene mRNA detect circulating HCC cells as adjuvant diagnostic tool and as indicators of recurrence and prognosis (Wu 2006)
    Marker
    Therapy target
    ANIMAL & CELL MODELS