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FLASH GENE
Symbol CLDN3 contributors: mct/npt - updated : 21-01-2013
HGNC name claudin 3
HGNC id 2045
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • four putative transmembrane segments
    • HOMOLOGY
    interspecies homolog to rattus ventral prostate 1
    Homologene
    FAMILY
  • claudin family
    • CATEGORY adhesion , structural protein
    SUBCELLULAR LOCALIZATION     plasma membrane,junction,tight
    text integral membrane protein
    basic FUNCTION
  • tight junction specific obliteration of the intercelular space
  • creating charge specific channels in the paracellular space
  • involved in the formation and function of tight junctions (Honda 2007)
  • decreasing the airway tight junctional permeability (Coyne 2003)
  • roles for CLDN3 and CLDN4 in alveolar epithelial barrier function
  • both CLDN3 and CLDN4 mediate interactions with other cells that restrain growth and metastatic potential by sustaining expression of E-cadherin and limiting CTNNB1 signaling
  • tight junction protein regulating the paracellular permeability of cell layers
  • role of CLDN3 and CLDN10 in decidual angiogenesis and regulation of trophoblast invasion
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • major structural components of tight junction (TJ) strands
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacted strongly with CLDN8 and CLDN7, normal TJ constituents in the collecting duct
  • CLDN4 accumulates CLDN1 and CLDN3 in TJs to enhance cell-cell contact in renal tubular epithelial cells
  • GRHL2 regulates epithelial morphogenesis through transcriptional up-regulation of CLDN3 and CLDN4, as well as of RAB25, which increases the CLDN4 protein and its localization at TJs
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in colorectal cancer
    tumoral     --over  
    in 90 p100 of ovarian cancers (Huang 2009)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancer  
    anti-claudin-3 and -4 bispecific monoclonal antibody shows promise in the development of a diagnostic and therapeutic antibody for cancers
    cancerdigestivecolon
    potential markers and therapy target in colorectal cancer
    cancerreproductiveovary
    may be a promising target for antibody-based therapy of ovarian carcinomas
    cancerreproductiveovary
    lipidoid-formulated CLDN3 siRNA has potential as a therapeutic for ovarian cancer
    ANIMAL & CELL MODELS