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FLASH GENE

Symbol

CLDN3

contributors: mct/npt - updated : 21-01-2013

HGNC name	claudin 3
HGNC id	2045

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

EXPRESSION

Type

widely

expressed in

(based on citations)

organ(s)

System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive liver       highly Endocrine pancreas       highly Hearing/Equilibrium ear inner cochlea       ear inner vestibule     Reproductive female system uterus     highly Homo sapiens Respiratory lung       highly   lung       highly Homo sapiens Urinary kidney tubule Henles loop HL ascending limb highly Homo sapiens

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Epithelial barrier lining endometrium     Homo sapiens

cells

System Cell Pubmed Species Stage Rna symbol   fibroblast Hearing / Equilibrium cochlea cell Hearing / Equilibrium epithelial cell Respiratory alveolar cell type II Homo sapiens Respiratory epithelial cell Homo sapiens

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

four putative transmembrane segments

HOMOLOGY

interspecies

homolog to rattus ventral prostate 1

Homologene

FAMILY

claudin family

CATEGORY

adhesion , structural protein

SUBCELLULAR LOCALIZATION	plasma membrane,junction,tight
text	integral membrane protein

basic FUNCTION	tight junction specific obliteration of the intercelular space
	creating charge specific channels in the paracellular space
	involved in the formation and function of tight junctions (Honda 2007)
	decreasing the airway tight junctional permeability (Coyne 2003)
	roles for CLDN3 and CLDN4 in alveolar epithelial barrier function
	both CLDN3 and CLDN4 mediate interactions with other cells that restrain growth and metastatic potential by sustaining expression of E-cadherin and limiting CTNNB1 signaling
	tight junction protein regulating the paracellular permeability of cell layers
	role of CLDN3 and CLDN10 in decidual angiogenesis and regulation of trophoblast invasion

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

major structural components of tight junction (TJ) strands

INTERACTION

DNA

RNA

small molecule

protein	interacted strongly with CLDN8 and CLDN7, normal TJ constituents in the collecting duct
	CLDN4 accumulates CLDN1 and CLDN3 in TJs to enhance cell-cell contact in renal tubular epithelial cells
	GRHL2 regulates epithelial morphogenesis through transcriptional up-regulation of CLDN3 and CLDN4, as well as of RAB25, which increases the CLDN4 protein and its localization at TJs

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   in colorectal cancer tumoral     --over   in 90 p100 of ovarian cancers (Huang 2009)

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed cancer     anti-claudin-3 and -4 bispecific monoclonal antibody shows promise in the development of a diagnostic and therapeutic antibody for cancers cancer digestive colon potential markers and therapy target in colorectal cancer cancer reproductive ovary may be a promising target for antibody-based therapy of ovarian carcinomas cancer reproductive ovary lipidoid-formulated CLDN3 siRNA has potential as a therapeutic for ovarian cancer

ANIMAL & CELL MODELS