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FLASH GENE
Symbol FER contributors: mct/npt - updated : 05-04-2008
HGNC name fer (fps/fes related) tyrosine kinase (phosphoprotein NCP94)
HGNC id 3655
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N-terminal sequences can affect their ability to induce phosphorylation of STAT3 and most probably direct different cellular functions
    • HOMOLOGY
    intraspecies homolog to fer (fps/fes related) oncogene
    Homologene
    FAMILY
  • protein kinase superfamily
  • Tyr protein kinase family
  • FPS family
    • CATEGORY enzyme , protooncogene
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    basic FUNCTION
  • non receptor tyrosine kinase, required for cell-cycle progression in malignant cells
  • implicated in signaling downstream from cytokines, growth factors and immune receptors
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with NRP1 ( having a function in signaling SEMA3A-evoked neuronal death through FER in cortical neurons) (Jiang 2010)
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS