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FLASH GENE

Symbol

FER

contributors: mct/npt - updated : 05-04-2008

HGNC name	fer (fps/fes related) tyrosine kinase (phosphoprotein NCP94)
HGNC id	3655

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

EXPRESSION

Type

widely

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive liver       highly   mouth       highly Lymphoid/Immune spleen       highly

cells

System Cell Pubmed Species Stage Rna symbol Blood/Hematopoietic platelet

cell lineage	lymphoid cells (JAK family)
cell lines
fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

N-terminal sequences can affect their ability to induce phosphorylation of STAT3 and most probably direct different cellular functions

HOMOLOGY

intraspecies

homolog to fer (fps/fes related) oncogene

Homologene

FAMILY	protein kinase superfamily
	Tyr protein kinase family
	FPS family

CATEGORY

enzyme , protooncogene

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm
	intracellular,nucleus

basic FUNCTION	non receptor tyrosine kinase, required for cell-cycle progression in malignant cells
	implicated in signaling downstream from cytokines, growth factors and immune receptors

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

interacting with NRP1 ( having a function in signaling SEMA3A-evoked neuronal death through FER in cortical neurons) (Jiang 2010)

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS