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FLASH GENE
Symbol FER contributors: mct/npt - updated : 05-04-2008
HGNC name fer (fps/fes related) tyrosine kinase (phosphoprotein NCP94)
HGNC id 3655
Location 5q21.3      Physical location : 108.083.522 - 108.523.373
Synonym name
  • tyrosine kinase 3
  • phosphoprotein NCP94
    • Synonym symbol(s) TYK3, p94-FER, c-FER
    EC.number 2.7.10.2
    DNA
    TYPE functioning gene
    STRUCTURE 439.85 kb     20 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked   status confirmed
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    20 - 2950 - 822 - -
    EXPRESSION
    Type widely
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveliver   highly
     mouth   highly
    Lymphoid/Immunespleen   highly
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticplatelet
    cell lineage lymphoid cells (JAK family)
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • N-terminal sequences can affect their ability to induce phosphorylation of STAT3 and most probably direct different cellular functions
    • HOMOLOGY
    intraspecies homolog to fer (fps/fes related) oncogene
    Homologene
    FAMILY
  • protein kinase superfamily
  • Tyr protein kinase family
  • FPS family
    • CATEGORY enzyme , protooncogene
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    basic FUNCTION
  • non receptor tyrosine kinase, required for cell-cycle progression in malignant cells
  • implicated in signaling downstream from cytokines, growth factors and immune receptors
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with NRP1 ( having a function in signaling SEMA3A-evoked neuronal death through FER in cortical neurons) (Jiang 2010)
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS