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FLASH GENE
Symbol ADH4 contributors: mct - updated : 09-09-2010
HGNC name alcohol dehydrogenase 4 (class II), pi polypeptide
HGNC id 252
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
conjugated MetalloP
mono polymer homomer , dimer
HOMOLOGY
interspecies ortholog to rattus Adh4
ortholog to murine Adh4
Homologene
FAMILY
  • zinc-containing alcohol dehydrogenase family
  • class-II subfamily
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    text found in outer cell layers, lining the lumen (Vaglenova 2003)
    basic FUNCTION
  • contributes, in addition to alcohol, to the metabolization of a wide variety of substrates, including retinol, other aliphatic alcohols, hydroxysteroids, and biogenic amines (Rainero 2010)
  • acting as retinol dehydrogenase/retinal reductase, also sites of active retinoid metabolism in the gut, essential for mucosa function and vitamin A absorption (Vaglenova 2003)
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism alcohol , other
    signaling
    long chain aliphatic and aromatic alcohols
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Zn2+ (2 ions per subunit)
    • protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    increased expression of ADH1A and ADH4 in non-alcoholic steatohepatitis livers (baker 2010)
    Susceptibility
  • to alcoholism
  • to cluster headache
    • Variant & Polymorphism SNP
  • 12SNPs significantly associated to alcoholism
  • rs1126671 polymorphism resulted significantly different between cluster headache patients and controls (Rainero 2010)
    • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS