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FLASH GENE

Symbol

ADH4

contributors: mct - updated : 09-09-2010

HGNC name	alcohol dehydrogenase 4 (class II), pi polypeptide
HGNC id	252

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

EXPRESSION

Type	restricted

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive esophagus       highly   intestine large intestine rectum   highly   intestine large intestine colon   highly   liver       specific   stomach       highly

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

conjugated

MetalloP

mono polymer

homomer , dimer

HOMOLOGY

interspecies	ortholog to rattus Adh4
	ortholog to murine Adh4

Homologene

FAMILY	zinc-containing alcohol dehydrogenase family
	class-II subfamily

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm
text	found in outer cell layers, lining the lumen (Vaglenova 2003)

basic FUNCTION	contributes, in addition to alcohol, to the metabolization of a wide variety of substrates, including retinol, other aliphatic alcohols, hydroxysteroids, and biogenic amines (Rainero 2010)
	acting as retinol dehydrogenase/retinal reductase, also sites of active retinoid metabolism in the gut, essential for mucosa function and vitamin A absorption (Vaglenova 2003)

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

alcohol , other

signaling

long chain aliphatic and aromatic alcohols

a component

INTERACTION

DNA

RNA

small molecule	metal binding,
	Zn2+ (2 ions per subunit)

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --over   increased expression of ADH1A and ADH4 in non-alcoholic steatohepatitis livers (baker 2010)

Susceptibility

to alcoholism to cluster headache

Variant & Polymorphism SNP	12SNPs significantly associated to alcoholism
	rs1126671 polymorphism resulted significantly different between cluster headache patients and controls (Rainero 2010)

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS