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FLASH GENE
Symbol KRT6A contributors: npt/mct - updated : 26-12-2006
HGNC name keratin 6A
HGNC id 6443
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • conserved central rod domain, made of four helical domains (1A, 1B, 2A, 2B) interrupted by non alpha helical linkers (L1, 2, 3)
  • the homology domains H1 and H2, by variable region (V1, V2), end sequences (E1, E2)
    • mono polymer heteromer , dimer
    HOMOLOGY
    interspecies ortholog to murine Krt2-6a
    homolog to C.elegans F58E10.3
    Homologene
    FAMILY
  • intermediate filament protein
  • type II keratin family
    • CATEGORY structural protein
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton,intermed filament
    text expressed with family members KRT16 and/or KRT17
    basic FUNCTION
  • required for filament assembly
    • CELLULAR PROCESS cell life, proliferation/growth
    cell organization/biogenesis
    PHYSIOLOGICAL PROCESS development
    text
  • ectoderm development
  • cell shape and cell size control
    • PATHWAY
    metabolism
    signaling
    a component
  • dimerizing with KRT16, KRT17
  • heterodimer of a type I (acidic) and a type II (neutral to basic) keratin
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding to KRT16, KRT17
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) PC112
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
    K6-null mice (Wong,2000)