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FLASH GENE

Symbol

KRT6A

contributors: npt/mct - updated : 26-12-2006

HGNC name	keratin 6A
HGNC id	6443

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

EXPRESSION

Type	ubiquitous

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol digestive esophagus         Endocrine pancreas       highly Nervous brain       highly Reproductive male system prostate     highly Skin/Tegument skin palm         skin sole         skin appendages nails         skin appendages hair follicle

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Epithelial absorptive excretory digestive epithelium     Epithelial barrier/lining uroepithelium     Epithelial secretory glandular exocrine   Epithelial secretory glandular endocrine   Epithelial sensory gustatory

cells

System Cell Pubmed Species Stage Rna symbol Skin/Tegument keratinocyte

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	conserved central rod domain, made of four helical domains (1A, 1B, 2A, 2B) interrupted by non alpha helical linkers (L1, 2, 3)
	the homology domains H1 and H2, by variable region (V1, V2), end sequences (E1, E2)

mono polymer

heteromer , dimer

HOMOLOGY

interspecies	ortholog to murine Krt2-6a
	homolog to C.elegans F58E10.3

Homologene

FAMILY	intermediate filament protein
	type II keratin family

CATEGORY

structural protein

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,cytoskeleton,intermed filament
text	expressed with family members KRT16 and/or KRT17

basic FUNCTION

required for filament assembly

CELLULAR PROCESS	cell life, proliferation/growth
	cell organization/biogenesis

PHYSIOLOGICAL PROCESS

development

text	ectoderm development
	cell shape and cell size control

PATHWAY

metabolism

signaling

a component	dimerizing with KRT16, KRT17
	heterodimer of a type I (acidic) and a type II (neutral to basic) keratin

INTERACTION

DNA

RNA

small molecule

protein

binding to KRT16, KRT17

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

PC112

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS

K6-null mice (Wong,2000)