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FLASH GENE
Symbol RNF207 contributors: mct - updated : 21-09-2018
HGNC name ring finger protein 207
HGNC id 32947
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY
CATEGORY enzyme
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm
intracellular,nuclear envelope
basic FUNCTION
  • plays a role in cardiac energy metabolism
  • RNF207 is involved in ATP production by cardiomyocytes, suggesting that RNF207 plays an important role in the development of heart failure
  • RNF207 is an important regulator of action potential duration, likely via effects on KCNH2 trafficking and localization in a heat shock protein-dependent manner
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • RNF207 and KCNH2 potassium channel interact and colocalize
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
    Rnf207 was significantly reduced in mice with common cardiac diseases including heart failure