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FLASH GENE
Symbol RNF207 contributors: mct - updated : 21-09-2018
HGNC name ring finger protein 207
HGNC id 32947
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   specific Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY
CATEGORY enzyme
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm
intracellular,nuclear envelope
basic FUNCTION
  • plays a role in cardiac energy metabolism
  • RNF207 is involved in ATP production by cardiomyocytes, suggesting that RNF207 plays an important role in the development of heart failure
  • RNF207 is an important regulator of action potential duration, likely via effects on KCNH2 trafficking and localization in a heat shock protein-dependent manner
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • RNF207 and KCNH2 potassium channel interact and colocalize
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
    Rnf207 was significantly reduced in mice with common cardiac diseases including heart failure