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FLASH GENE

Symbol

RNF207

contributors: mct - updated : 21-09-2018

HGNC name	ring finger protein 207
HGNC id	32947

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	1p36.31      Physical location : 6.266.188 - 6.281.351
Synonym symbol(s)	c1orf188

DNA

TYPE	functioning gene
STRUCTURE	15.29 kb     18 Exon(s)

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_207396 18 - 3987 NP_997279 - 634 - 2014 25281747

EXPRESSION

Type	restricted

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart       specific Homo sapiens

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

HOMOLOGY

Homologene

FAMILY

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm
	intracellular,nuclear envelope

basic FUNCTION	plays a role in cardiac energy metabolism
	RNF207 is involved in ATP production by cardiomyocytes, suggesting that RNF207 plays an important role in the development of heart failure
	RNF207 is an important regulator of action potential duration, likely via effects on KCNH2 trafficking and localization in a heat shock protein-dependent manner

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

RNF207 and KCNH2 potassium channel interact and colocalize

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS

Rnf207 was significantly reduced in mice with common cardiac diseases including heart failure