| basic FUNCTION
| hydrolase activity, acting on carbon-nitrogen bonds in linear amides |
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Golgi enzyme, regulating ITGB1 maturation by controlling the generation of sphingosine  |
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plays an important role in cellular responses by regulating the hydrolysis of ceramides in cells |
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has likely broad substrate specificity and requires Ca(2+) for its activity and ACER2 has the cytosolic C terminus and luminal N terminus, which are essential for its activity, correct cellular localization, and regulation for protein glycosylation (PMIDS: |
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alkaline ceramidase activity is important for the generation of SPH, the S1P precursor in erythrocytes |
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ACER2 upregulation mediates PCD in response to DNA damage through sphingosine |
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ACER2/sphingosine pathway mediates programmed cell death (PCD) in response to DNA damage through ROS production |
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is involved in programed cell death in response to DNA damage |
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ACER2 required Ca2+ for both its in vitro and cellular activities and its N-terminal tail is necessary for both ACER2 activity and Golgi localization |
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plays a key role in the maintenance of high plasma levels of sphingoid base-1-phosphates-S1P and dihydrosphingosine (dhSPH)-by controlling the generation of sphingoid bases-SPH and dhSPH-in hematopoietic cells |
