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FLASH GENE

Symbol

ACER2

contributors: mct - updated : 03-07-2018

HGNC name	N-acylsphingosine amidohydrolase 3-like
HGNC id	23675

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_001010887 6 - 2852 NP_001010887 31.3 275 - 2006 16940153

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive mouth tongue       Reproductive female system placenta     highly Homo sapiens Respiratory respiratory tract larynx

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Muscular

cells

System Cell Pubmed Species Stage Rna symbol Blood/Hematopoietic erythrocyte Homo sapiens

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	N-terminal tail is necessary for both ACER2 activity and Golgi localization
	7 putative transmembrane domains
	its amino (N) and carboxyl (C) termini were found to be oriented in the lumen of the Golgi complex and cytosol, respectively

HOMOLOGY

Homologene

FAMILY

alkaline ceramidase family

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,membrane
	intracellular,cytoplasm,organelle,Golgi
text	localized to the Golgi complex

basic FUNCTION	hydrolase activity, acting on carbon-nitrogen bonds in linear amides
	Golgi enzyme, regulating ITGB1 maturation by controlling the generation of sphingosine
	plays an important role in cellular responses by regulating the hydrolysis of ceramides in cells
	has likely broad substrate specificity and requires Ca(2+) for its activity and ACER2 has the cytosolic C terminus and luminal N terminus, which are essential for its activity, correct cellular localization, and regulation for protein glycosylation (PMIDS:
	alkaline ceramidase activity is important for the generation of SPH, the S1P precursor in erythrocytes
	ACER2 upregulation mediates PCD in response to DNA damage through sphingosine
	ACER2/sphingosine pathway mediates programmed cell death (PCD) in response to DNA damage through ROS production
	is involved in programed cell death in response to DNA damage
	ACER2 required Ca2+ for both its in vitro and cellular activities and its N-terminal tail is necessary for both ACER2 activity and Golgi localization
	plays a key role in the maintenance of high plasma levels of sphingoid base-1-phosphates-S1P and dihydrosphingosine (dhSPH)-by controlling the generation of sphingoid bases-SPH and dhSPH-in hematopoietic cells

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

lipid/lipoprotein

signaling

ACER2/sphingosine pathway plays an important role in regulating ITGB1 maturation and cell adhesion mediated by beta1 integrins

a component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS