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FLASH GENE
Symbol ACER2 contributors: mct - updated : 03-07-2018
HGNC name N-acylsphingosine amidohydrolase 3-like
HGNC id 23675
Location 9p22.1      Physical location : 19.408.924 - 19.452.500
Synonym name
  • alkaline ceramidase 2
  • ceramide hydrolase
  • AlkCDase 2
    • Synonym symbol(s) FLJ41587, ASAH3L, ALKCDase2
    EC.number 3.5.1.23
    DNA
    TYPE functioning gene
    STRUCTURE 46.25 kb     6 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    6 - 2852 31.3 275 - 2006 16940153
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivemouthtongue   
    Reproductivefemale systemplacenta  highly Homo sapiens
    Respiratoryrespiratory tractlarynx   
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscular    
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticerythrocyte Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • N-terminal tail is necessary for both ACER2 activity and Golgi localization
  • 7 putative transmembrane domains
  • its amino (N) and carboxyl (C) termini were found to be oriented in the lumen of the Golgi complex and cytosol, respectively
    • HOMOLOGY
    Homologene
    FAMILY
  • alkaline ceramidase family
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,Golgi
    text localized to the Golgi complex
    basic FUNCTION
  • hydrolase activity, acting on carbon-nitrogen bonds in linear amides
  • Golgi enzyme, regulating ITGB1 maturation by controlling the generation of sphingosine
  • plays an important role in cellular responses by regulating the hydrolysis of ceramides in cells
  • has likely broad substrate specificity and requires Ca(2+) for its activity and ACER2 has the cytosolic C terminus and luminal N terminus, which are essential for its activity, correct cellular localization, and regulation for protein glycosylation (PMIDS:
  • alkaline ceramidase activity is important for the generation of SPH, the S1P precursor in erythrocytes
  • ACER2 upregulation mediates PCD in response to DNA damage through sphingosine
  • ACER2/sphingosine pathway mediates programmed cell death (PCD) in response to DNA damage through ROS production
  • is involved in programed cell death in response to DNA damage
  • ACER2 required Ca2+ for both its in vitro and cellular activities and its N-terminal tail is necessary for both ACER2 activity and Golgi localization
  • plays a key role in the maintenance of high plasma levels of sphingoid base-1-phosphates-S1P and dihydrosphingosine (dhSPH)-by controlling the generation of sphingoid bases-SPH and dhSPH-in hematopoietic cells
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism lipid/lipoprotein
    signaling
  • ACER2/sphingosine pathway plays an important role in regulating ITGB1 maturation and cell adhesion mediated by beta1 integrins
    • a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS