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FLASH GENE
Symbol STYXL1 contributors: mct - updated : 04-10-2016
HGNC name serine/threonine/tyrosine interacting-like 1
HGNC id 18165
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a rhodanese domain
  • a tyrosine-protein phosphatase domain
  • a Ser residue instead of a conserved Cys residue in the dsPTPase catalytic loop which probably renders it catalytically inactive as a phosphatase
  • a binding pocket for phosphorylated substrates
    • HOMOLOGY
    interspecies ortholog to murine Dusp24
    Homologene
    FAMILY
  • dual-specificity phosphatase subfamily of the PTPs (protein tyrosine phosphatases)
  • non-receptor class subfamily
    • CATEGORY enzyme , signaling
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria
    text
  • localize to the mitochondria but is neither released from the mitochondria upon apoptotic stress nor proximal to the machinery currently known to control mitochondrial outer membrane permeabilization
    • basic FUNCTION
  • probable pseudophosphatase
  • acting as a protein tyrosine/serine/threonine phosphatase
  • having a role for MK-STYX in regulating the ability of G3BP1 to integrate changes in growth-factor stimulation and environmental stress with the regulation of protein synthesis
  • catalytically inactive phosphatase with homology to the mitogen-activated protein kinase (MAPK) phosphatases
  • regulates mitochondrial outer membrane permeabilization using a distinct mechanism
  • plays a key role in the cellular response to stress
  • STYX and MAPK-STYX (STYXL1), are integral signaling molecules in regulating pathways involved in neuronal developmental processes such as neurite outgrowth
  • very specific role of STYX and STYXL1 for each pseudophosphatase, further highlighting the relevance of these atypical members of DUSP as signaling regulators
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
  • intracellular signaling cascade
    • a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • G3BP1 a regulator of Ras signalling, is a binding partner of STYXL1
  • STYXL1 controls apoptosis by negatively regulating PTPMT1
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS