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FLASH GENE
Symbol STYXL1 contributors: mct - updated : 04-10-2011
HGNC name serine/threonine/tyrosine interacting-like 1
HGNC id 18165
DNA
TYPE functioning gene
STRUCTURE 51.67 kb     9 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
9 splicing 1429 53 313 - 1998 9757831
- splicing - 28 247 - Dayton
- splicing - 36 318 - Dayton
- splicing - 24 217 - Walker
- splicing - 12 111 - Walker
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinelarge intestinecolon highly
 pancreas exocrine   moderately
Nervousbrain   moderately
Reproductivefemale systemovary  predominantly
Respiratorylung   moderately
 respiratory tractlarynx  moderately
Urinarykidney   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / hematopoieticbone marrow   
Connectivebone   
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a rhodanese domain
  • a tyrosine-protein phosphatase domain
  • a Ser residue instead of a conserved Cys residue in the dsPTPase catalytic loop which probably renders it catalytically inactive as a phosphatase
  • a binding pocket for phosphorylated substrates
  • HOMOLOGY
    interspecies ortholog to murine Dusp24
    Homologene
    FAMILY
  • dual-specificity phosphatase subfamily of the PTPs (protein tyrosine phosphatases)
  • non-receptor class subfamily
  • CATEGORY enzyme , signaling
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria
    text
  • localize to the mitochondria but is neither released from the mitochondria upon apoptotic stress nor proximal to the machinery currently known to control mitochondrial outer membrane permeabilization
  • basic FUNCTION
  • probable pseudophosphatase
  • acting as a protein tyrosine/serine/threonine phosphatase
  • having a role for MK-STYX in regulating the ability of G3BP1 to integrate changes in growth-factor stimulation and environmental stress with the regulation of protein synthesis
  • catalytically inactive phosphatase with homology to the mitogen-activated protein kinase (MAPK) phosphatases
  • regulates mitochondrial outer membrane permeabilization using a distinct mechanism
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
  • intracellular signaling cascade
  • a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein G3BP1 a regulator of Ras signalling, is a binding partner of STYXL1
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS