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FLASH GENE

Symbol

STYXL1

contributors: mct - updated : 04-10-2016

HGNC name	serine/threonine/tyrosine interacting-like 1
HGNC id	18165

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	7q11.23      Physical location : 75.625.655 - 75.677.321
Synonym name	map kinase phosphatase-like protein
	MAPK (mitogen-activated protein kinase) phospho-serine/threonine/tyrosine-binding protein
	dual specificity phosphatase inhibitor MK-STYX
	dual specificity phosphatase 24
	dual specificity phosphatase 24 (putative)
Synonym symbol(s)	MK-STYX, DUSP24

DNA

TYPE	functioning gene
STRUCTURE	51.67 kb     9 Exon(s)

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_016086 9 splicing 1429 53 313 - 1998 9757831 variant 2 - splicing - 28 247 - Dayton variant 3 - splicing - 36 318 - Dayton variant 4 - splicing - 24 217 - Walker variant 5 - splicing - 12 111 - Walker

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive intestine large intestine colon   highly   pancreas exocrine       moderately Nervous brain       moderately Reproductive female system ovary     predominantly Respiratory lung       moderately   respiratory tract larynx     moderately Urinary kidney       highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / hematopoietic bone marrow       Connective bone

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a rhodanese domain
	a tyrosine-protein phosphatase domain
	a Ser residue instead of a conserved Cys residue in the dsPTPase catalytic loop which probably renders it catalytically inactive as a phosphatase
	a binding pocket for phosphorylated substrates

HOMOLOGY

interspecies

ortholog to murine Dusp24

Homologene

FAMILY	dual-specificity phosphatase subfamily of the PTPs (protein tyrosine phosphatases)
	non-receptor class subfamily

CATEGORY

enzyme , signaling

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,mitochondria
text	localize to the mitochondria but is neither released from the mitochondria upon apoptotic stress nor proximal to the machinery currently known to control mitochondrial outer membrane permeabilization

basic FUNCTION	probable pseudophosphatase
	acting as a protein tyrosine/serine/threonine phosphatase
	having a role for MK-STYX in regulating the ability of G3BP1 to integrate changes in growth-factor stimulation and environmental stress with the regulation of protein synthesis
	catalytically inactive phosphatase with homology to the mitogen-activated protein kinase (MAPK) phosphatases
	regulates mitochondrial outer membrane permeabilization using a distinct mechanism
	plays a key role in the cellular response to stress
	STYX and MAPK-STYX (STYXL1), are integral signaling molecules in regulating pathways involved in neuronal developmental processes such as neurite outgrowth
	very specific role of STYX and STYXL1 for each pseudophosphatase, further highlighting the relevance of these atypical members of DUSP as signaling regulators

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

signal transduction

intracellular signaling cascade

a component

INTERACTION

DNA

RNA

small molecule

protein	G3BP1 a regulator of Ras signalling, is a binding partner of STYXL1
	STYXL1 controls apoptosis by negatively regulating PTPMT1

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS