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FLASH GENE
Symbol NUP37 contributors: mct - updated : 26-06-2019
HGNC name nucleoporin 37kDa
HGNC id 29929
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
four WD repeats
mono polymer complex
HOMOLOGY
interspecies ortholog to murine Nup37
Homologene
FAMILY
CATEGORY transport channel
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm,cytosolic
intracellular,nucleus,nucleoplasm
intracellular,nucleus,chromatin/chromosome,kinetochore
intracellular,nuclear envelope,pore
text
  • nuclear pore complex
  • targeted to kinetochores from prophase to anaphase during mitosis
    • basic FUNCTION
  • may mediate the assembly of subdomains of the NPC or facilitate the interaction of transport complexes with the NPC
  • NUP37 and AHCTF1 are stable architectural nucleoporins that occur, independent of one another
  • oncogenic roles of NUP37 in the progression of hepatocellular carcinoma
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    text
  • protein transport
    • PATHWAY
    metabolism
    signaling
    a component
  • nuclear pore complex
  • part of one such subcomplex, NUP107-160
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • NUP37 interacted with YAP1 and activated YAP1/TEAD1 signaling by enhancing the interaction between YAP1 and TEAD1
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) MCPH24
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    promoted the growth, migration and invasion of Hepatocellular carcinoma cells
    Susceptibility
    Variant & Polymorphism
    Candidate gene
  • NUP37, NUP43, and NUP188 are novel candidate genes for cardiovascular disease
    • Marker
    Therapy target
    ANIMAL & CELL MODELS