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FLASH GENE

Symbol

NUP37

contributors: mct - updated : 26-06-2019

HGNC name	nucleoporin 37kDa
HGNC id	29929

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	45.95 kb     9 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_024057 10 - 1310 NP_076962 - 326 - 2007 17360435

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive intestine small intestine     highly Respiratory respiratory tract larynx     highly

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

four WD repeats

mono polymer

complex

HOMOLOGY

interspecies

ortholog to murine Nup37

Homologene

FAMILY

CATEGORY

transport channel

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,cytosolic
	intracellular,nucleus,nucleoplasm
	intracellular,nucleus,chromatin/chromosome,kinetochore
	intracellular,nuclear envelope,pore
text	nuclear pore complex
	targeted to kinetochores from prophase to anaphase during mitosis

basic FUNCTION	may mediate the assembly of subdomains of the NPC or facilitate the interaction of transport complexes with the NPC
	NUP37 and AHCTF1 are stable architectural nucleoporins that occur, independent of one another
	oncogenic roles of NUP37 in the progression of hepatocellular carcinoma

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

text	protein transport

PATHWAY

metabolism

signaling

a component	nuclear pore complex
	part of one such subcomplex, NUP107-160

INTERACTION

DNA

RNA

small molecule

protein

NUP37 interacted with YAP1 and activated YAP1/TEAD1 signaling by enhancing the interaction between YAP1 and TEAD1

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

MCPH24

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   promoted the growth, migration and invasion of Hepatocellular carcinoma cells

Susceptibility

Variant & Polymorphism

Candidate gene	NUP37, NUP43, and NUP188 are novel candidate genes for cardiovascular disease
Marker
Therapy target

ANIMAL & CELL MODELS