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FLASH GENE
Symbol NUP37 contributors: mct - updated : 26-06-2019
HGNC name nucleoporin 37kDa
HGNC id 29929
Corresponding disease
MCPH24 microcephaly 24, primary, autosomal recessive
Location 12q23.3      Physical location : 102.467.974 - 102.512.361
Synonym name
  • NUP107-160 subcomplex subunit NUP37
    • Synonym symbol(s) MGC5585, FLJ22618, p37
    DNA
    TYPE functioning gene
    STRUCTURE 45.95 kb     9 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    10 - 1310 - 326 - 2007 17360435
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinesmall intestine  highly
    Respiratoryrespiratory tractlarynx  highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    		four WD repeats
    mono polymer complex
    HOMOLOGY
    interspecies ortholog to murine Nup37
    Homologene
    FAMILY
    CATEGORY transport channel
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus,nucleoplasm
    intracellular,nucleus,chromatin/chromosome,kinetochore
    intracellular,nuclear envelope,pore
    text
  • nuclear pore complex
  • targeted to kinetochores from prophase to anaphase during mitosis
    • basic FUNCTION
  • may mediate the assembly of subdomains of the NPC or facilitate the interaction of transport complexes with the NPC
  • NUP37 and AHCTF1 are stable architectural nucleoporins that occur, independent of one another
  • oncogenic roles of NUP37 in the progression of hepatocellular carcinoma
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    text
  • protein transport
    • PATHWAY
    metabolism
    signaling
    a component
  • nuclear pore complex
  • part of one such subcomplex, NUP107-160
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • NUP37 interacted with YAP1 and activated YAP1/TEAD1 signaling by enhancing the interaction between YAP1 and TEAD1
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) MCPH24
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    promoted the growth, migration and invasion of Hepatocellular carcinoma cells
    Susceptibility
    Variant & Polymorphism
    Candidate gene
  • NUP37, NUP43, and NUP188 are novel candidate genes for cardiovascular disease
    • Marker
    Therapy target
    ANIMAL & CELL MODELS