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FLASH GENE
Symbol HELZ2 contributors: mct - updated : 19-03-2014
HGNC name helicase with zinc finger 2, transcriptional coactivator
HGNC id 30021
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • five Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs, multiple LXXLL motifs in PDIP1 not required for the interaction
  • one C2H2-type zinc finger
  • C-terminal region directly binds DBD of PPARgamma
    • HOMOLOGY
    Homologene
    FAMILY
  • DNA2/NAM7 helicase family
    • CATEGORY enzyme , regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleoplasm
    basic FUNCTION
  • helicase acting as a transcriptional coactivator for peroxisome proliferator activated receptor alpha (PPAR-alpha)
  • might function as a transcriptional cofactor for a broad range of nuclear receptors, possibly in collaboration with specific activation function-2 interacting coactivators
    • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • probably part of the peroxisome proliferator activated receptor alpha interacting complex (PRIC)
    • INTERACTION
    DNA binding
    RNA binding
    small molecule metal binding, nucleotide,
  • ATP
  • Zn2+
    • protein
  • PPARA
  • ESR1
  • THRB
  • RXRA
  • interacts with the serine/arginine-rich domain and BCL2 associated transcription factor1-homologous region in THRAP3, whereas THRAP3 directly binds 2 helicase motifs in HELZ2
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS