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FLASH GENE

Symbol

HELZ2

contributors: mct - updated : 19-03-2014

HGNC name	helicase with zinc finger 2, transcriptional coactivator
HGNC id	30021

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive intestine small intestine     moderately Lymphoid/Immune lymph node       highly   spleen       moderately Reproductive female system breast mammary gland   highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Connective adipose     highly

cell lineage
cell lines
fluid/secretion	blood

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	five Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs, multiple LXXLL motifs in PDIP1 not required for the interaction
	one C2H2-type zinc finger
	C-terminal region directly binds DBD of PPARgamma

HOMOLOGY

Homologene

FAMILY

DNA2/NAM7 helicase family

CATEGORY

enzyme , regulatory

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,nucleus,nucleoplasm

basic FUNCTION	helicase acting as a transcriptional coactivator for peroxisome proliferator activated receptor alpha (PPAR-alpha)
	might function as a transcriptional cofactor for a broad range of nuclear receptors, possibly in collaboration with specific activation function-2 interacting coactivators

CELLULAR PROCESS

nucleotide, transcription, regulation

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

probably part of the peroxisome proliferator activated receptor alpha interacting complex (PRIC)

INTERACTION

DNA

binding

RNA

binding

small molecule	metal binding, nucleotide,
	ATP
	Zn2+

protein	PPARA
	ESR1
	THRB
	RXRA
	interacts with the serine/arginine-rich domain and BCL2 associated transcription factor1-homologous region in THRAP3, whereas THRAP3 directly binds 2 helicase motifs in HELZ2

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS