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FLASH GENE
Symbol HELZ2 contributors: mct - updated : 19-03-2014
HGNC name helicase with zinc finger 2, transcriptional coactivator
HGNC id 30021
Location 20q13.33      Physical location : -
Genatlas name peroxisomal proliferator-activated receptor A interacting complex 285
Synonym name
  • ATP-dependent helicase PRIC285
  • PPAR gamma DBD-interacting protein 1
  • PRIC complex
  • Synonym symbol(s) FLJ00244, KIAA1769, PDIP1, MGC132634, MGC138228, PRIC285
    EC.number 3.6.1.-
    DNA
    TYPE functioning gene
    STRUCTURE 16.15 kb     20 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    - splicing 8864 285 2567 - 2006 1623930
    14 splicing 7507 231 2080 - 2006 1623930
    variant 2 or PDIP1 alpha
    20 splicing 10002 294 2649 expressed more abundantly than PDIP1alpha mRNA 2006 1623930
    variant 1 or PDIP1 beta
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinesmall intestine  moderately
    Lymphoid/Immunelymph node   highly
     spleen   moderately
    Reproductivefemale systembreastmammary gland highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectiveadipose  highly
    cell lineage
    cell lines
    fluid/secretion blood
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • five Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs, multiple LXXLL motifs in PDIP1 not required for the interaction
  • one C2H2-type zinc finger
  • C-terminal region directly binds DBD of PPARgamma
  • HOMOLOGY
    Homologene
    FAMILY
  • DNA2/NAM7 helicase family
  • CATEGORY enzyme , regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleoplasm
    basic FUNCTION
  • helicase acting as a transcriptional coactivator for peroxisome proliferator activated receptor alpha (PPAR-alpha)
  • might function as a transcriptional cofactor for a broad range of nuclear receptors, possibly in collaboration with specific activation function-2 interacting coactivators
  • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • probably part of the peroxisome proliferator activated receptor alpha interacting complex (PRIC)
  • INTERACTION
    DNA binding
    RNA binding
    small molecule metal binding, nucleotide,
  • ATP
  • Zn2+
  • protein
  • PPARA
  • ESR1
  • THRB
  • RXRA
  • interacts with the serine/arginine-rich domain and BCL2 associated transcription factor1-homologous region in THRAP3, whereas THRAP3 directly binds 2 helicase motifs in HELZ2
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS