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FLASH GENE
Symbol ATP5O contributors: - updated : 18-10-2006
HGNC name ATP synthase, H+ transporting, mitochondrial F1 complex, O subunit (oligomycin sensitivity conferring protein)
HGNC id 850
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a 23 aa transit peptide (2.4 kda)
  • isoforms Precursor a 189 aa mature peptide (20.9 kda)
    HOMOLOGY
    interspecies homolog to rattus Atp5o (81.7pc)
    homolog to murine Atp5o (82.2pc)
    Homologene
    FAMILY
  • ATPase delta chain family
  • CATEGORY enzyme , transport
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria,inner
    intracellular,cytoplasm,organelle,mitochondria,matrix
    basic FUNCTION
  • acting as a catalytic unit of the ATP synthesis
  • being part of the stalk that links CF(0) to CF(1)
  • transmiting conformational changes from CF(0) into CF(1)
  • implicated in proton conduction
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    text
  • protein
  • proton
  • PATHWAY
    metabolism energetic
    signaling
  • oxydative phosphorylation
  • a component
  • constituent of mitochondrial matrix F0 segment
  • component of complex V of oxidative phosphorylation (OXPHOS)
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    inhibited by immunomodulatory benzodiazepine Bz-423 (in vitro)
    ASSOCIATED DISORDERS
    corresponding disease(s)
    related resource MITOP database
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target for lupus
    ANIMAL & CELL MODELS