Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol ATP5O contributors: - updated : 18-10-2006
HGNC name ATP synthase, H+ transporting, mitochondrial F1 complex, O subunit (oligomycin sensitivity conferring protein)
HGNC id 850
Location 21q22.1-q22.2      Physical location : 35.275.757 - 35.288.158
Synonym name
  • oligomycin sensitivity conferring protein
  • Synonym symbol(s) ATPO, OSCP
    EC.number 3.6.3.14
    DNA
    TYPE functioning gene
    STRUCTURE 12.00 kb     7 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked   status confirmed
    RNA
    TRANSCRIPTS type messenger
    EXPRESSION
    Type ubiquitous
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   highly
    Endocrineadrenal gland   moderately
     parathyroid   highly
    Lymphoid/Immunetonsils   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumskeletal  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal
    Text umbilical cord
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a 23 aa transit peptide (2.4 kda)
  • isoforms Precursor a 189 aa mature peptide (20.9 kda)
    HOMOLOGY
    interspecies homolog to rattus Atp5o (81.7pc)
    homolog to murine Atp5o (82.2pc)
    Homologene
    FAMILY
  • ATPase delta chain family
  • CATEGORY enzyme , transport
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria,inner
    intracellular,cytoplasm,organelle,mitochondria,matrix
    basic FUNCTION
  • acting as a catalytic unit of the ATP synthesis
  • being part of the stalk that links CF(0) to CF(1)
  • transmiting conformational changes from CF(0) into CF(1)
  • implicated in proton conduction
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    text
  • protein
  • proton
  • PATHWAY
    metabolism energetic
    signaling
  • oxydative phosphorylation
  • a component
  • constituent of mitochondrial matrix F0 segment
  • component of complex V of oxidative phosphorylation (OXPHOS)
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    inhibited by immunomodulatory benzodiazepine Bz-423 (in vitro)
    ASSOCIATED DISORDERS
    corresponding disease(s)
    related resource MITOP database
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target for lupus
    ANIMAL & CELL MODELS