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FLASH GENE
Symbol ATP5O contributors: - updated : 18-10-2006
HGNC name ATP synthase, H+ transporting, mitochondrial F1 complex, O subunit (oligomycin sensitivity conferring protein)
HGNC id 850
DNA
TYPE functioning gene
STRUCTURE 12.00 kb     7 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked   status confirmed
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type ubiquitous
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   highly
Endocrineadrenal gland   moderately
 parathyroid   highly
Lymphoid/Immunetonsils   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumskeletal  
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period fetal
Text umbilical cord
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a 23 aa transit peptide (2.4 kda)
  • isoforms Precursor a 189 aa mature peptide (20.9 kda)
    HOMOLOGY
    interspecies homolog to rattus Atp5o (81.7pc)
    homolog to murine Atp5o (82.2pc)
    Homologene
    FAMILY
  • ATPase delta chain family
  • CATEGORY enzyme , transport
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria,inner
    intracellular,cytoplasm,organelle,mitochondria,matrix
    basic FUNCTION
  • acting as a catalytic unit of the ATP synthesis
  • being part of the stalk that links CF(0) to CF(1)
  • transmiting conformational changes from CF(0) into CF(1)
  • implicated in proton conduction
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    text
  • protein
  • proton
  • PATHWAY
    metabolism energetic
    signaling
  • oxydative phosphorylation
  • a component
  • constituent of mitochondrial matrix F0 segment
  • component of complex V of oxidative phosphorylation (OXPHOS)
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    inhibited by immunomodulatory benzodiazepine Bz-423 (in vitro)
    ASSOCIATED DISORDERS
    corresponding disease(s)
    related resource MITOP database
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target for lupus
    ANIMAL & CELL MODELS