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FLASH GENE
Symbol TBC1D10A contributors: mct/npt - updated : 16-06-2017
HGNC name TBC1 domain family, member 10A
HGNC id 23609
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N-terminal Tre-2/Bub2/Cdc16 (TBC) domain that stabilizes active ARF6, has RabGAP activity, and is required for the accumulation of vacuoles
  • a PDZ domain
    • HOMOLOGY
    interspecies homolog to murine Tbc1d10
    Homologene
    FAMILY
    CATEGORY unknown/unspecified
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • PDZ-domain binding activity
  • TBC domain-containing protein that regulates microvillar subdomains and structure
  • GTPase-activating protein specific for RAB27A
  • TBC1D10A, TBC1D10C regulate exosome secretion in a catalytic activity-dependent manner
  • apical microvillar protein, regulating ARF6-dependent membrane trafficking
  • regulates membrane trafficking both by stabilizing ARF6-GTP and by inhibiting the recycling of membrane through the tubular endosome by decreasing RAB8A-GTP levels
  • TBC1D10A, CYTH2 regulate endocytosis at distinct stages
  • TBC1D10A, TBC1D10B, TBC1D10C, having the physiological and pathological functions such as melanosome transport, exosome secretion, and T-cell activation
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binds the PDZ domains of SLC9A3R1, which binds ezrin, a major actin-binding protein of microvilli
  • TBC1D10A interacts with SYTL1 to coordinate RAB8A and ARF6 membrane trafficking
  • peripheral CYTH2 recruits TBC1D10A to the same area and the interaction requires glucose-induced endocytosis in pancreatic beta-cells
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS